Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Read More
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Read More
Most Useful Reviews
9
Seizure stability
6 people found this helpful
After surviving a heart attack in September 2019, I faced a recurrence shortly after. Following the recommendation of a book by Dr. Mitsuishi and Dr. Fujikawa, I began taking this supplement. Since then, I haven’t experienced any further seizures, and my wife's “trigger finger” has improved. I'm unsure which supplement is responsible as I was using several, but I appreciate the benefits we’ve noticed.
Read More
7.5
Notable improvement
16 people found this helpful
I experienced significant numbness in my feet and toes. After taking this B12 supplement for about three weeks, I feel a 60% improvement. There's also a slight reduction in my anxiety and depressive symptoms. I'll continue to monitor my reactions to this supplement, as we are all unique. If this helps, please acknowledge!
Read More
6
Reduction in pain
3 people found this helpful
I prefer taking vitamins separately instead of in complex forms, as this allows for better dosage control. I developed carpal tunnel syndrome due to my work and suffered from numbness and pain in my fingers. I recognised a lack of vitamin B12 and decided to supplement it, which alleviated the numbness and discomfort. The combination of exercises and B12 has been beneficial. Glory to Ukraine 💙💛
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
- All Researches
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Read More
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Seizure stability
6 people found this helpful
After surviving a heart attack in September 2019, I faced a recurrence shortly after. Following the recommendation of a book by Dr. Mitsuishi and Dr. Fujikawa, I began taking this supplement. Since then, I haven’t experienced any further seizures, and my wife's “trigger finger” has improved. I'm unsure which supplement is responsible as I was using several, but I appreciate the benefits we’ve noticed.
Read More
7.5
Notable improvement
16 people found this helpful
I experienced significant numbness in my feet and toes. After taking this B12 supplement for about three weeks, I feel a 60% improvement. There's also a slight reduction in my anxiety and depressive symptoms. I'll continue to monitor my reactions to this supplement, as we are all unique. If this helps, please acknowledge!
Read More
6
Reduction in pain
3 people found this helpful
I prefer taking vitamins separately instead of in complex forms, as this allows for better dosage control. I developed carpal tunnel syndrome due to my work and suffered from numbness and pain in my fingers. I recognised a lack of vitamin B12 and decided to supplement it, which alleviated the numbness and discomfort. The combination of exercises and B12 has been beneficial. Glory to Ukraine 💙💛
Read More
7.5
Enhanced energy
2 people found this helpful
A good quality B12 tablet recommended by my doctor, I've only been taking it for a couple of weeks. The tablet is small and easy to take. Since beginning this supplement for heart health, I'm feeling markedly less tired. I will continue using this product.
Read More
9
Heart health
Within two weeks of taking this vitamin, my hair loss and nail breaking have ceased. I also feel more at ease regarding my heart health. I recommend this to everyone as B12 is often lacking in our diets.
Read More
Frequently Asked Questions
7.5
Enhanced energy
2 people found this helpful
A good quality B12 tablet recommended by my doctor, I've only been taking it for a couple of weeks. The tablet is small and easy to take. Since beginning this supplement for heart health, I'm feeling markedly less tired. I will continue using this product.
7.5
Notable improvement
16 people found this helpful
I experienced significant numbness in my feet and toes. After taking this B12 supplement for about three weeks, I feel a 60% improvement. There's also a slight reduction in my anxiety and depressive symptoms. I'll continue to monitor my reactions to this supplement, as we are all unique. If this helps, please acknowledge!
9
Heart health
Within two weeks of taking this vitamin, my hair loss and nail breaking have ceased. I also feel more at ease regarding my heart health. I recommend this to everyone as B12 is often lacking in our diets.
6
Reduction in pain
3 people found this helpful
I prefer taking vitamins separately instead of in complex forms, as this allows for better dosage control. I developed carpal tunnel syndrome due to my work and suffered from numbness and pain in my fingers. I recognised a lack of vitamin B12 and decided to supplement it, which alleviated the numbness and discomfort. The combination of exercises and B12 has been beneficial. Glory to Ukraine 💙💛
9
Seizure stability
6 people found this helpful
After surviving a heart attack in September 2019, I faced a recurrence shortly after. Following the recommendation of a book by Dr. Mitsuishi and Dr. Fujikawa, I began taking this supplement. Since then, I haven’t experienced any further seizures, and my wife's “trigger finger” has improved. I'm unsure which supplement is responsible as I was using several, but I appreciate the benefits we’ve noticed.
7.5
Daily supplement
I've found B12 to be incredibly beneficial, contributing to increased energy, improved brain function, better heart health, nerve protection, and red blood cell production. I'm now on my third order of this daily supplement, which comes in small, easy-to-swallow capsules and I take two a day.
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
References
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. doi:10.1371/journal.pone.0275956
- Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. doi:10.1111/joim.12834
